Article
Identification of a novel antigen cross-presenting cell type in spleen.
Journal of cellular and molecular medicine - 1 May 2011
Tan Jonathan K H, Quah Ben J C, Griffiths Kristin L, Periasamy Pravin, Hey Ying-Ying, O'Neill Helen C
Abstract excerpt
Antigen-presenting cells (APC), like dendritic cells (DC), are essential for T-cell activation, leading to immunity or tolerance. Multiple DC subsets each play a unique role in the immune response. Here, a novel splenic dendritic-like APC has been characterized in mice that has immune function and cell surface phenotype distinct from other, described DC subsets. These were identified as a cell type continuously...
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