Article
Steady state pig dendritic cells migrating in skin draining pseudo-afferent lymph are semi-mature.
Veterinary immunology and immunopathology - 15 Dec 2011
Bertho Nicolas, Marquet Florian, Pascale Florentina, Kang Chantal, Bonneau Michel, Schwartz-Cornil Isabelle
Abstract excerpt
Dendritic cells (DC) in peripheral tissues are considered as immature cells that mature and migrate towards lymph nodes upon stimulation with pathogens. This commonly accepted paradigm is challenged by the fact that tolerance to peripheral self antigen is controlled by mature DC and that DC collected from afferent lymph draining different tissues from several species, in the absence of pathogen signaling, were...
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