Article

A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways

2021-10-08

Abstract excerpt

<h4>ABSTRACT</h4> The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require the ubiquitin-proteasome system (UPS) for their generation, this conclusion has been challenged. T...

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Literature Corpus work: 7915c990-ff1b-5203-8778-508b65589fbf
DOI: 10.1101/2021.10.07.463289

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