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Article

Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition.

Developmental cell - 18 May 2020

Sanaki Yuya, Nagata Rina, Kizawa Daisuke, Léopold Pierre, Igaki Tatsushi

Abstract excerpt

Metabolic diseases such as type 2 diabetes are associated with increased cancer incidence. Here, we show that hyperinsulinemia promotes epithelial tumorigenesis by abrogating cell competition. In Drosophila eye imaginal epithelium, oncogenic scribble (scrib) mutant cells are eliminated by cell competition when surrounded by wild-type cells. Through a genetic screen, we find that flies heterozygous for the insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32386602
DOI: 10.1016/j.devcel.2020.04.008

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