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Article

Oncogenic Ras, Yki and Notch signals converge to confer clone competitiveness through Upd2.

Journal of genetics and genomics = Yi chuan xue bao - 1 Jan 2026

Wang Ying, Huang Rui, Deng Minfeng, He Jingjing, Deng Mingxi, Ishibashi Toyotaka, Yu Cong, Zhai Zongzhao, Yan Yan

Abstract excerpt

Cell competition is an evolutionarily ancient mechanism that functions to remove unfit or dangerous clonal cells in a multicellular community. A classical model is the removal of polarity-deficient clones, such as the precancerous scribble (scrib) mutant clones, in Drosophila imaginal discs. The activation of Ras, Yki, or Notch signaling robustly reverses the scrib mutant clonal fate from elimination to tumorous...

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PMID: 40320143
DOI: 10.1016/j.jgg.2025.04.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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