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Article

Allele-specific amplification in cancer revealed by SNP array analysis.

PLoS computational biology - 1 Nov 2005

LaFramboise Thomas, Weir Barbara A, Zhao Xiaojun, Beroukhim Rameen, Li Cheng, Harrington David, Sellers William R, Meyerson Matthew

Abstract excerpt

Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, loss-of-heterozygosity events have been finely mapped using high-throughput genotyping technologies. We have developed a probe-level allele-specific quantitation procedure that extracts both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16322765
DOI: 10.1371/journal.pcbi.0010065
PMCID: PMC1289392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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