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Article

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs.

British journal of clinical pharmacology - 1 Feb 2002

Bertilsson Leif, Dahl Marja-Liisa, Dalén Per, Al-Shurbaji Ayman

Abstract excerpt

Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug-metabolizing enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive trait; these subjects (7% of Caucasians, about 1% of Orientals) are classified as poor metabolizers. Among the rest (extensive metabolizers), enzyme activity is highly variable, from extremely high in ultrarapid metabolizers, to markedly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11851634
DOI: 10.1046/j.0306-5251.2001.01548.x
PMCID: PMC1874287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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