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Article

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients.

Oncotarget - 1 Dec 2011

Mäkinen Netta, Heinonen Hanna-Riikka, Moore Shane, Tomlinson Ian P M, van der Spuy Zephne M, Aaltonen Lauri A

Abstract excerpt

Uterine leiomyomas, or fibroids, are extremely common tumors. Regardless of their benign nature, fibroids can cause considerable morbidity. Women with African ancestry have a threefold increased risk of developing uterine leiomyomas with a greater symptom severity when compared to white women. Recently, we demonstrated that exon 2 of the MED12 gene is somatically altered in up to 70 per cent of uterine leiomyomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22182697
DOI: 10.18632/oncotarget.370
PMCID: PMC3282101

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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MED12 exon 2 mutations are common in uterine leiomyomas from South African patients.PMID 22182697Read ↗

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Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients.Semantic proximity Read ↗

Comprehensive screening for MED12 mutations in gynaecological mesenchymal tumours identified morphologically distinctive mixed epithelial and stromal tumours.Semantic proximity Read ↗

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