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Article

The impact of RB1 genotype on incidence of second tumours in heritable retinoblastoma.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2020

Ketteler Petra, Hülsenbeck Isabel, Frank Mirjam, Schmidt Börge, Jöckel Karl-Heinz, Lohmann Dietmar R

Abstract excerpt

BACKGROUND: Patients with heritable retinoblastoma are at risk for bilateral retinoblastoma and second primary malignancies (SPMs). The incidence of SPM is significantly raised after radiotherapy. We analysed the impact of the class of constitutional RB1 variant on the incidence of SPM in survivors with and without previous radiotherapy. METHODS: From 1940 to 2008, 655 national patients were treated for heritable...

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Identifiers

PMID: 32434110
DOI: 10.1016/j.ejca.2020.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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