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Article

Dynamic disulfide scanning of the membrane-inserting Pf3 coat protein reveals multiple YidC substrate contacts.

The Journal of biological chemistry - 3 Feb 2012

Klenner Christian, Kuhn Andreas

Abstract excerpt

The membrane insertase YidC inserts newly synthesized proteins into the plasma membrane. While defects in YidC homologs in animals and plants cause diseases, YidC in bacteria is essential for life. Membrane insertion and assembly of ATP synthase and respiratory complexes is catalyzed by YidC. To investigate how YidC interacts with membrane-inserting proteins, we generated single cysteine mutants in YidC and in...

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Identifiers

PMID: 22179606
DOI: 10.1074/jbc.M111.307223
PMCID: PMC3281698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamic disulfide scanning of the membrane-inserting Pf3 coat protein reveals multiple YidC substrate contacts.PMID 22179606Read ↗

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Each protomer of a dimeric YidC functions as a single membrane insertase.Semantic proximity Read ↗

Features of membrane protein sequence direct post-translational insertion.Semantic proximity Read ↗

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