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Article

Substrate-dependent conformational dynamics of the Escherichia coli membrane insertase YidC.

Biochemistry - 19 Apr 2011

Imhof Nora, Kuhn Andreas, Gerken Uwe

Abstract excerpt

The binding of Pf3 coat protein to the membrane insertase YidC from Escherichia coli induces a conformational change in the tertiary structure of the insertase, resulting in a quenching of the intrinsic tryptophan (Trp) fluorescence. Tryptophan mutants of YidC were generated to examine such conformational movements in detail with time-resolved and steady-state fluorescence spectroscopy. Ten of the 11 Trp residues...

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Identifiers

PMID: 21401071
DOI: 10.1021/bi1020293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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