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Article

Conditional lethal mutations separate the M13 procoat and Pf3 coat functions of YidC: different YIDC structural requirements for membrane protein insertion.

The Journal of biological chemistry - 27 Jun 2003

Chen Minyong, Xie Kun, Nouwen Nico, Driessen Arnold J M, Dalbey Ross E

Abstract excerpt

Conditional lethal YidC mutants have been isolated to decipher the role of YidC in the assembly of Sec-dependent and Sec-independent membrane proteins. We now show that the membrane insertion of the Sec-independent M13 procoat-lep protein is inhibited in a short time in a temperature-sensitive mu...

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Source

Identifiers

PMID: 12707259
DOI: 10.1074/jbc.M301008200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-12707259-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Conditional lethal mutations separate the M13 procoat and Pf3 coat functions of YidC: different YIDC structural requirements for membrane protein insertion.PMID 12707259Read ↗

Involvement of SecDF and YidC in the membrane insertion of M13 procoat mutants.Semantic proximity Read ↗

Dynamic disulfide scanning of the membrane-inserting Pf3 coat protein reveals multiple YidC substrate contacts.Semantic proximity Read ↗

Each protomer of a dimeric YidC functions as a single membrane insertase.Semantic proximity Read ↗

The Pf3 coat protein contacts TM1 and TM3 of YidC during membrane biogenesis.Semantic proximity Read ↗

The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential.Semantic proximity Read ↗

Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein.Semantic proximity Read ↗

M13 procoat protein insertion into YidC and SecYEG proteoliposomes and liposomes.Semantic proximity Read ↗

Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity.Semantic proximity Read ↗

A mutation in the Escherichia coli secY gene that produces distinct effects on inner membrane protein insertion and protein export.Semantic proximity Read ↗

Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function.Semantic proximity Read ↗

The conserved third transmembrane segment of YidC contacts nascent Escherichia coli inner membrane proteins.Semantic proximity Read ↗

Different regions of the nonconserved large periplasmic domain of Escherichia coli YidC are involved in the SecF interaction and membrane insertase activity.Semantic proximity Read ↗

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