Evolutionary History and Strength of Selection Determine the Rate of Antibiotic Resistance Adaptation.

Abstract excerpt

Bacterial adaptation to stressful environments often produces evolutionary constraints whereby increases in resistance are associated with reduced fitness in a different environment. The exploitation of this resistance-cost trade-off has been proposed as the basis of rational antimicrobial treatm...

Topics

• Adaptation, Physiological
• Anti-Bacterial Agents
• Drug Resistance, Bacterial
• Escherichia coli
• Mutation