Article
[Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences - 18 Dec 2011
Liu Yuan, Zhong Shi-long, Yang Min, Tan Hong-hong, Fei Hong-wen, Chen Ji-yan, Yu Xi-yong, Lin Shu-guang
Abstract excerpt
OBJECTIVE: To investigate distribution of CYP2C9, CYP3A4, VKORC1 and GGCX gene polymorphisms in the Han population of Guangdong. METHODS: The subjects included were 970 Chinese Han patients who received long-term warfarin anticoagulant therapy orally after valve replacement in Guangdong General Hospital between 2000 and 2008. By selecting and analyzing the 12 single nucleotide polymorphisms (SNPs) loci,...
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