Article
[Impact of CYP2C9 and VKORC1 polymorphism on warfarin response during initiation of therapy].
Zhonghua xin xue guan bing za zhi - 1 Oct 2011
Liu Yuan, Zhong Shi-long, Tan Hong-hong, Yang Min, Fei Hong-wen, Yu Xi-yong, Lin Shu-guang
Abstract excerpt
OBJECTIVE: To investigate potential contributions of genetic variants of cytochrome P-450 2C9 (CYP2C9) and vitamin K expoxide reductase (VKORC1) to the anticoagulation response during the initiation of warfarin therapy in the Han Chinese population. METHODS: A total of 798 Han Chinese patients received long-term warfarin anticoagulant therapy orally after valve replacement in our hospital between 2000 and 2008...
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