Article
Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages.
Clinical immunology (Orlando, Fla.) - 1 Mar 2012
Kadowaki Takeshi, Arikawa Tomohiro, Shinonaga Rika, Oomizu Souichi, Inagawa Hiroyuki, Soma Genichiro, Niki Toshiro, Hirashima Mitsuomi
Abstract excerpt
Galectin-9 (Gal-9) expanded plasmacytoid dendritic cell-like macrophages (pDC-Mϕs) in lung cancer-bearing mice and prolonged the survival. Gal-9 increased the frequency of CD11c(high) cells in M-CSF- but not GM-CSF-induced Mϕs in vitro in a Tim-3 independent manner. CD11c(high) cells differentiated with M-CSF+Gal-9 expressed pDC-Mϕ markers, such as PDCA-1 and F4/80. These cells expressed high TLR7, TLR8 and TLR9,...
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