Article
Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.
Clinical immunology (Orlando, Fla.) - 1 Mar 2009
Nobumoto Atsuya, Oomizu Souichi, Arikawa Tomohiro, Katoh Shigeki, Nagahara Keiko, Miyake Minoru, Nishi Nozomu, Takeshita Keisuke, Niki Toshiro, Yamauchi Akira, Hirashima Mitsuomi
Abstract excerpt
Galectin-9 (Gal-9) inhibits the metastasis of tumor cells by blocking their adhesion to endothelium and the extracellular matrix. In this study, we addressed the involvement of Gal-9 in anti-tumor activity. Gal-9 significantly prolonged the survival of B16F10 melanoma-bearing mice. Gal-9 increased the numbers of NK cells, CD8 T cells and macrophages in tumor-bearing mice. Gal-9-mediated anti-tumor activity was...
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