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Plasmacytoid Dendritic Cells Mediate CpG-ODN–induced Increase in Survival in a Mouse Model of Lymphangioleiomyomatosis

11 Jul 2024

Abstract excerpt

Lymphangioleiomyomatosis (LAM) is a devastating disease primarily found in women of reproductive age that leads to cystic destruction of the lungs. Recent work has shown that LAM causes immunosuppression and that checkpoint inhibitors can be used as LAM treatment. Toll-like receptor (TLR) agonists can also reactivate immunity, and the TLR9 agonist CpG oligodeoxynucleotide (CpG-ODN) has been effective in treating...

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Identifiers

PMID: 38990702
DOI: 10.1165/rcmb.2023-0410oc

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