Article

Galectin-1 upregulates IDO1 and PD-L1 and induces a tolerogenic tumor-associated macrophage phenotype

2022-08-18

Abstract excerpt

<title>Abstract</title> <p>Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we used an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimulated with galectin-1 and show that galectin-1 induces a tolerogenic macrophage phenotype with increased expression of key immune checkpoint...

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Literature Corpus work: f2dca6b0-3f2e-5f9c-9085-67be190d74a7
DOI: 10.21203/rs.3.rs-1936493/v1

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