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Article

Effects of the CYP oxidoreductase Ala503Val polymorphism on CYP3A activity in vivo: a randomized, open-label, crossover study in healthy Chinese men.

Clinical therapeutics - 1 Dec 2011

Yang Guoping, Fu Zhimin, Chen Xiaoping, Yuan Hong, Yang Heng, Huang Yuanyuan, Ouyang Dongsheng, Tan Zhirong, Tan Hongyi, Huang Zhijun, Zhou Honghao

Abstract excerpt

BACKGROUND: Cytochrome P450 (CYP) oxidoreductase (POR) is the electron donor for microsomal CYP enzymes. The POR Ala503Val (POR*28 C > T) polymorphism has been reported to influence CYP3A activity in vivo in a white population. The influence of this polymorphism on CYP3A activity in vivo in the Chinese population currently unknown. OBJECTIVE: This study was designed to assess the influence of the POR*28...

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Identifiers

PMID: 22177374
DOI: 10.1016/j.clinthera.2011.11.004

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POR

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