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Article

Effect of breviscapine on CYP3A metabolic activity in healthy volunteers.

European journal of clinical pharmacology - 1 Jan 2018

Zhou Xuan, Gao Yang-Yang, Hu Jian-Yong, Dong Yu, Zhang Hai-Zhu, Lai Yong

Abstract excerpt

OBJECTIVE: The purpose of this study was to investigate the influence of breviscapine on the pharmacokinetics of concomitantly administered midazolam (MID) and its associations with and effects on genetic polymorphism of the gene encoding cytochrome P450 3A5 (CYP3A5) in healthy volunteers. METHODS: The study group comprised 17 healthy volunteers who had been genotyped for CYP3A5*3 prior to start of the study....

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Source

Identifiers

PMID: 28986606
DOI: 10.1007/s00228-017-2346-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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