Article
The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.
Pharmacogenetics and genomics - 1 Nov 2009
Oneda Beatrice, Crettol Severine, Jaquenoud Sirot Evelyne, Bochud Murielle, Ansermot Nicolas, Eap Chin B
Abstract excerpt
BACKGROUND: CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about 50% of drugs on the market, with a large overlap in their specificities. We investigated the genetic bases that contribute to the variation of CYP3A activity. METHODS: We phenotyped 251 individuals from two independent studies (182 patients treated with methadone and 69 patients with clozapine) for CYP3A activity using the midazolam...
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