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Article

Effects of cytochrome P450 oxidoreductase genotypes on the pharmacokinetics of amlodipine in healthy Korean subjects.

Molecular genetics & genomic medicine - 1 May 2020

Han Ji Min, Yee Jeong, Chung Jee Eun, Lee Kyung Eun, Park Kyungsoo, Gwak Hye Sun

Abstract excerpt

BACKGROUND: The aim of this study was to investigate the effects of P450 oxidoreductase (POR) genetic polymorphisms on the pharmacokinetic parameters of amlodipine. METHODS: After a single 10-mg dose of amlodipine administration, 25 healthy male subjects completed genotyping for 12 single nucleotide polymorphisms (SNPs) of the POR genes, cytochrome P450 (CYP)3A4 g.25343G>A (CYP3A4*1G), and CYP3A5 g.12083G>A...

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Identifiers

PMID: 32134573
DOI: 10.1002/mgg3.1201
PMCID: PMC7216797

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