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Article

Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.

Pharmacogenetics and genomics - 1 Mar 2013

Elens Laure, Nieuweboer Annemieke J M, Clarke Stephen J, Charles Kellie A, de Graan Anne-Joy M, Haufroid Vincent, van Gelder Teun, Mathijssen Ron H J, van Schaik Ron H N

Abstract excerpt

OBJECTIVE: P450 oxidoreductase (POR) is essential for cytochrome P450 (CYP) activity in humans. The POR*28 allele (A503V) has been shown to impact on in-vitro CYP-mediated metabolism, including CYP3A isoenzymes. The aim of the present study was to determine the in vivo impact of the POR*28 allele...

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Source

Identifiers

PMID: 23324807
DOI: 10.1097/FPC.0b013e32835dc113

Genes

POR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23324807-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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