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Article

Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.

PLoS genetics - 1 Aug 2020

Busayavalasa Kiran, Ruiz Mario, Devkota Ranjan, Ståhlman Marcus, Bodhicharla Rakesh, Svensk Emma, Hermansson Nils-Olov, Borén Jan, Pilon Marc

Abstract excerpt

The C. elegans proteins PAQR-2 (a homolog of the human seven-transmembrane domain AdipoR1 and AdipoR2 proteins) and IGLR-2 (a homolog of the mammalian LRIG proteins characterized by a single transmembrane domain and the presence of immunoglobulin domains and leucine-rich repeats in their extracellular portion) form a complex that protects against plasma membrane rigidification by promoting the expression of fatty...

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Identifiers

PMID: 32750056
DOI: 10.1371/journal.pgen.1008975
PMCID: PMC7428288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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