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A Novel Enterococcus faecalis Heme Transport Regulator (FhtR) Senses Host Heme To Control Its Intracellular Homeostasis

1 Feb 2021

Abstract excerpt

Enterococcus faecalis , a normal and harmless colonizer of the human intestinal flora can cause severe infectious diseases in immunocompromised patients, particularly those that have been heavily treated with antibiotics. Therefore, it is important to understand the factors that promote its resistance and its virulence. E. faecalis , which cannot synthesize heme, an essential but toxic metabolite, needs to...

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PMID: 33531389
DOI: 10.1128/mbio.03392-20

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