Article
A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2012
Hartmaier R J, Richter A S, Gillihan R M, Sallit J Z, McGuire S E, Wang J, Lee A V, Osborne C K, O'Malley B W, Brown P H, Xu J, Skaar T C, Philips S, Rae J M, Azzouz F, Li L, Hayden J, Henry N L, Nguyen A T, Stearns V, Hayes D F, Flockhart D A, Oesterreich S
Abstract excerpt
The coregulator steroid receptor coactivator (SRC)-1 increases transcriptional activity of the estrogen receptor (ER) in a number of tissues including bone. Mice deficient in SRC-1 are osteopenic and display skeletal resistance to estrogen treatment. SRC-1 is also known to modulate effects of selective ER modulators like tamoxifen. We hypothesized that single nucleotide polymorphisms (SNP) in SRC-1 may impact...
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