The SH2B gene is associated with serum leptin and body fat in normal female twins.

doi:10.1038/oby.2007.637

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Article

The SH2B gene is associated with serum leptin and body fat in normal female twins.

Obesity (Silver Spring, Md.) - 1 Jan 2007

Jamshidi Yalda, Snieder Harold, Ge Dongliang, Spector Tim D, O'Dell Sandra D

Abstract excerpt

Src-homology-2 (SH2)-B, a Janus tyrosine kinase 2-interacting protein, has been identified recently as a key regulator of leptin and insulin sensitivity, glucose homeostasis, and body weight in mice. The aim of this study was to determine whether single-nucleotide polymorphisms (SNPs) in the human SH2B gene are associated with these variables. A tagging SNP (tSNP), Ala484Thr (rs7498665), was selected to represent...

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PMID: 17228025
DOI: 10.1038/oby.2007.637
PMCID: PMC1780257

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