A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis.

doi:10.1210/endocr/bqab094

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A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis.

Endocrinology - 1 Aug 2021

Watters Rebecca J, Verdelis Kostas, Lucas Peter C, Jiang Shiming, Chen Yuqing, Lu Feiqi, Martin Benjamin M, Lukashova Lyuda, Pecar Geoffrey, Morales-Restrepo Alejandro, Hankins Margaret, Zhu Li, Mittwede Peter, Hartmaier Ryan J, Alexander Peter G, Tseng George C, Weiss Kurt R, Galson Deborah L, Lee Adrian V, Lee Brendan, Oesterreich Steffi

Abstract excerpt

The steroid receptor coactivator-1 (SRC-1) is a nuclear receptor co-activator, known to play key roles in both estrogen response in bone and in breast cancer metastases. We previously demonstrated that the P1272S single nucleotide polymorphism (SNP; P1272S; rs1804645) in SRC-1 decreases the activity of estrogen receptor in the presence of selective estrogen receptor modulators (SERMs) and that it is associated...

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PMID: 33963375
DOI: 10.1210/endocr/bqab094
PMCID: PMC8248588

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