Article
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling.
Oncogene - 25 Aug 2005
Kim Harold, Laing Mike, Muller William
Abstract excerpt
The c-Src tyrosine kinase has been implicated to play an integral role in modulating growth factor receptor, integrin and steroid receptor function. One class of steroid receptors that c-Src modulates is the estrogen receptor alpha (ERalpha). Although there is strong biochemical evidence supporting a role for c-Src in ERalpha signaling, the consequence of this association is unclear at the biological level. To...
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