Article
Decreased c-Src expression enhances osteoblast differentiation and bone formation.
The Journal of cell biology - 16 Oct 2000
Marzia M, Sims N A, Voit S, Migliaccio S, Taranta A, Bernardini S, Faraggiana T, Yoneda T, Mundy G R, Boyce B F, Baron R, Teti A
Abstract excerpt
c-src deletion in mice leads to osteopetrosis as a result of reduced bone resorption due to an alteration of the osteoclast. We report that deletion/reduction of Src expression enhances osteoblast differentiation and bone formation, contributing to the increase in bone mass. Bone histomorphometry showed that bone formation was increased in Src null compared with wild-type mice. In vitro, alkaline phosphatase...
Topics
- Alkaline Phosphatase
- Animals
- Bone Resorption
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Core Binding Factor Alpha 1 Subunit
- Gene Expression Regulation
- Mice
- Mice, Mutant Strains
- Neoplasm Proteins
- Oligonucleotides, Antisense
- Osteoblasts