Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

doi:10.1016/j.ccell.2015.07.005

Article

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

Cancer cell - 10 Aug 2015

Wang Lei, Yu Yang, Chow Dar-Chone, Yan Fei, Hsu Chih-Chao, Stossi Fabio, Mancini Michael A, Palzkill Timothy, Liao Lan, Zhou Suoling, Xu Jianming, Lonard David M, O'Malley Bert W

Abstract excerpt

By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics. High-throughput screening for SRC small molecule inhibitors (SMIs) uncovered MCB-613 as a potent SRC small molecule "stimulator" (SMS). We demonstrate that MCB-613 can super-stimulate SRCs' transcriptional activity. Further investigation revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

Abstract excerpt

Topics

Related research