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Article

Global Gene Repression by the Steroid Receptor Coactivator SRC-1 Promotes Oncogenesis

20 Mar 2014

Abstract excerpt

Transcriptional control is the major determinant of cell fate. The steroid receptor coactivator (SRC)-1 enhances the activity of the estrogen receptor in breast cancer cells, where it confers cell survival benefits. Here, we report that a global analysis of SRC-1 target genes suggested that SRC-1 also mediates transcriptional repression in breast cancer cells. Combined SRC-1 and HOXC11 ChIPseq analysis identified...

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PMID: 24648347
DOI: 10.1158/0008-5472.can-13-2133

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