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Article

Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.

Breast cancer research and treatment - 1 Feb 2011

Mehta Madhura S, Vazquez Alexei, Kulkarni Diptee A, Kerrigan John E, Atwal Gurinder, Metsugi Shoichi, Toppmeyer Deborah L, Levine Arnold J, Hirshfield Kim M

Abstract excerpt

TSC1 acts coordinately with TSC2 in a complex to inhibit mTOR, an emerging therapeutic target and known promoter of cell growth and cell cycle progression. Perturbation of the mTOR pathway, through abnormal expression or function of pathway genes, could lead to tumorigenesis. TSC1 and TSC2 expression is reduced in invasive breast cancer as compared with normal mammary epithelium. Because single nucleotide...

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Source

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Identifiers

PMID: 20658316
DOI: 10.1007/s10549-010-1062-1
PMCID: PMC3876413

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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