Article
In vitro and in vivo efficacy of PEGylated diisopropyl fluorophosphatase (DFPase).
Drug testing and analysis - 1 Jan 2000
Melzer Marco, Heidenreich Anne, Dorandeu Frederic, Gäb Jürgen, Kehe Kai, Thiermann Horst, Letzel Thomas, Blum Marc-Michael
Abstract excerpt
Highly toxic organophosphorus compounds that irreversibly inhibit the enzyme acetycholinesterase (AChE), including nerve agents like tabun, sarin, or soman, still pose a credible threat to civilian populations and military personnel. New therapeutics that can be used as a pretreatment or after poisoning with these compounds, complementing existing treatment schemes such as the use of atropine and AChE...
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