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Article

Neutron structure and mechanistic studies of diisopropyl fluorophosphatase (DFPase).

Acta crystallographica. Section D, Biological crystallography - 1 Nov 2010

Chen Julian C H, Mustyakimov Marat, Schoenborn Benno P, Langan Paul, Blum Marc Michael

Abstract excerpt

Diisopropyl fluorophosphatase (DFPase) is a calcium-dependent phosphotriesterase that acts on a variety of highly toxic organophosphorus compounds that act as inhibitors of acetylcholinesterase. The mechanism of DFPase has been probed using a variety of methods, including isotopic labelling, which demonstrated the presence of a phosphoenzyme intermediate in the reaction mechanism. In order to further elucidate...

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Identifiers

PMID: 21041927
DOI: 10.1107/S0907444910034013
PMCID: PMC2967418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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