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Sulfhydryl-specific PEGylation of phosphotriesterase cysteine mutants for organophosphate detoxification.

Protein engineering, design & selection : PEDS - 1 Nov 2015

Daffu Gurdip K, Lopez Patricia, Katz Francine, Vinogradov Michael, Zhan Chang-Guo, Landry Donald W, Macdonald Joanne

Abstract excerpt

The catalytic bioscavenger phosphotriesterase (PTE) is experimentally an effective antidote for organophosphate poisoning. We are interested in the molecular engineering of this enzyme to confer additional functionality, such as improved in vivo longevity. To this aim, we developed PTE cysteine mutants with free sulfhydryls to allow macromolecular attachments to the protein. A library of PTE cysteine mutants were...

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PMID: 26243887
DOI: 10.1093/protein/gzv036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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