Article
Nascentome analysis uncovers futile protein synthesis in Escherichia coli.
PloS one - 1 Jan 2011
Ito Koreaki, Chadani Yuhei, Nakamori Kenta, Chiba Shinobu, Akiyama Yoshinori, Abo Tatsuhiko
Abstract excerpt
Although co-translational biological processes attract much attention, no general and easy method has been available to detect cellular nascent polypeptide chains, which we propose to call collectively a "nascentome." We developed a method to selectively detect polypeptide portions of cellular polypeptidyl-tRNAs and used it to study the generality of the quality control reactions that rescue dead-end translation...
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