Article
A late-acting quality control process for mature eukaryotic rRNAs.
Molecular cell - 17 Nov 2006
LaRiviere Frederick J, Cole Sarah E, Ferullo Daniel J, Moore Melissa J
Abstract excerpt
Ribosome biogenesis is a multifaceted process involving a host of trans-acting factors mediating numerous chemical reactions, RNA conformational changes, and RNA-protein associations. Given this high degree of complexity, tight quality control is likely crucial to ensure structural and functional integrity of the end products. We demonstrate that ribosomal RNAs (rRNAs) containing individual point mutations, in...
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