Article
Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.
Kidney international - 1 Aug 2018
Schaefer Franz, Ardissino Gianluigi, Ariceta Gema, Fakhouri Fadi, Scully Marie, Isbel Nicole, Lommelé Åsa, Kupelian Varant, Gasteyger Christoph, Greenbaum Larry A, Johnson Sally, Ogawa Masayo, Licht Christoph, Vande Walle Johan, Frémeaux-Bacchi Véronique
Abstract excerpt
Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The Global aHUS Registry collects real-world data on the natural history of the disease. Here we characterize end-stage renal disease (ESRD)-free survival, the rate of thrombotic microangiopathy, organ involvement and the genetic background of 851 patients in the registry, prior to eculizumab treatment. A sex-specific...
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