Article
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory.
Neuron - 30 May 2002
Mazzucchelli Cristina, Vantaggiato Chiara, Ciamei Alessandro, Fasano Stefania, Pakhotin Pavel, Krezel Wojciech, Welzl Hans, Wolfer David P, Pagès Gilles, Valverde Olga, Marowsky Anne, Porrazzo Annamaria, Orban Paul C, Maldonado Rafael, Ehrengruber Markus U, Cestari Vincenzo, Lipp Hans-Peter, Chapman Paul F, Pouysségur Jacques, Brambilla Riccardo
Abstract excerpt
Extracellular signal-regulated kinases (ERK1 and 2) are synaptic signaling components necessary for several forms of learning. In mice lacking ERK1, we observe a dramatic enhancement of striatum-dependent long-term memory, which correlates with a facilitation of long-term potentiation in the nucleus accumbens. At the cellular level, we find that ablation of ERK1 results in a stimulus-dependent increase of ERK2...
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