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Article

Reversible acetylation of Lin28 mediated by PCAF and SIRT1.

Biochimica et biophysica acta - 1 Jun 2014

Wang Ling-xia, Wang Jing, Qu Ting-ting, Zhang Ye, Shen Yu-fei

Abstract excerpt

Lin28 is a small RNA-binding protein that plays an important role in regulating developmental timing, stem cell reprogramming, and oncogenesis. However, the significance of the effect of post-translational modifications on Lin28 activity is not fully understood. In this study, we demonstrated that PCAF directly interacted with and acetylated Lin28. We also showed that the acetylation of Lin28 can be specifically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24631505
DOI: 10.1016/j.bbamcr.2014.03.001

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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