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Article

Recognition of the let-7g miRNA precursor by human Lin28B.

FEBS letters - 16 Nov 2012

Ali P Shaik Syed, Ghoshdastider Umesh, Hoffmann Jan, Brutschy Bernd, Filipek Slawomir

Abstract excerpt

Mammalian homologs of lin28: Lin28 and Lin28B block the post-transcriptional processing of the let-7 family of miRNAs. We report that in vitro the terminal stem-loop region of the let-7g miRNA precursor (pre-let-7g) required to bind Lin28B is restricted to 24 nucleotides (nt) including the 3' GGAG motif. Additionally, full length Lin28B is required for efficient binding to pre-let-7g and the stoichiometry of the...

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PMID: 23063642
DOI: 10.1016/j.febslet.2012.09.034

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