Article
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.
RNA biology - 2 Dec 2017
Ransey Elizabeth, Björkbom Anders, Lelyveld Victor S, Biecek Przemyslaw, Pantano Lorena, Szostak Jack W, Sliz Piotr
Abstract excerpt
It remains a formidable challenge to characterize the diverse complexes of RNA binding proteins and their targets. While crosslink and immunoprecipitation (CLIP) methods are powerful techniques that identify RNA targets on a global scale, the resolution and consistency of these methods is a matter of debate. Here we present a comparative analysis of LIN28-pre-let-7 UV-induced crosslinking using a tandem mass...
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