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Article

Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells.

Mutation research - 1 Oct 1990

Morgan T L, Fleck E W, Poston K A, Denovan B A, Newman C N, Rossiter B J, Miller J H

Abstract excerpt

CHO-K1 cells were irradiated in plateau phase to determine the effect of dose, dose fractionation, and delayed replating on the type, location and frequency of mutations induced by 250 kVp X-rays at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus. Independent HPRT-deficient cell...

Topics

Animals
Blotting, Southern
Cells, Cultured
Chromosome Deletion
Chromosome Mapping
Cricetinae
Cricetulus
DNA Damage
DNA Repair
Dose-Response Relationship, Radiation
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

X-Rays

Source

Identifiers

PMID: 2215527
DOI: 10.1016/0027-5107(90)90122-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2215527-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells.PMID 2215527Read ↗

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