A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth.

Abstract excerpt

Heat response and heat-induced radiosensitization were studied in plateau-phase cultures of CHO cells and their radiation-sensitive counterpart, the xrs-5 cells. The xrs-5 cells were more sensitive to heat alone than were CHO cells. A large enhancement in radiation-induced killing was observed in CHO cells pre-exposed to heat (43 degrees C), expressed as a reduction in the values of Do and Dq. Contrary to the...

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