Article
A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000
Iliakis G, Seaner R
Abstract excerpt
Heat response and heat-induced radiosensitization were studied in plateau-phase cultures of CHO cells and their radiation-sensitive counterpart, the xrs-5 cells. The xrs-5 cells were more sensitive to heat alone than were CHO cells. A large enhancement in radiation-induced killing was observed in...
Topics
- Animals
- Cell Cycle
- Cell Division
- Cell Line
- Cell Survival
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Radiation
- Hot Temperature
- Mutation
- Radiation Tolerance