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Article

Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype.

Mutation research - 16 Nov 1992

Chang W P, Little J B

Abstract excerpt

Certain clonal progeny of Chinese hamster ovary (CHO) cells surviving X-irradiation demonstrate pleomorphic changes including a persistently decreased cloning efficiency, a dominant phenotype we have termed delayed reproductive death (Chang and Little, 1991, 1992b). We now report that cells from...

Topics

Animals
CHO Cells
Cell Cycle
Cell Death
Cell Survival
Clone Cells
Cricetinae
Cricetulus
Genes, Lethal
Hypoxanthine Phosphoribosyltransferase
Mutation
Phenotype

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Identifiers

PMID: 1383736
DOI: 10.1016/0027-5107(92)90130-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1383736-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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