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Article

APOBEC3-mediated editing in HIV type 1 from pediatric patients and its association with APOBEC3G/CUL5 polymorphisms and Vif variability.

AIDS research and human retroviruses - 1 Jun 2012

De Maio Federico A, Rocco Carlos A, Aulicino Paula C, Bologna Rosa, Mangano Andrea, Sen Luisa

Abstract excerpt

The APOBEC3 proteins are cytidine deaminases that can introduce G→A mutations in the HIV-1 plus DNA strand. This editing process may inhibit virus replication through lethal mutagenesis (hypermutation), but could also contribute to viral diversification leading to the emergence of escape forms. The HIV-1 Vif protein has the capacity to counteract APOBEC3 factors by recruiting a CUL5-based ubiquitin ligase complex...

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Source

Identifiers

PMID: 22145963
DOI: 10.1089/AID.2011.0291

Genes

CUL5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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