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Article

Unusual substitutions in HIV-1 vif from children infected perinatally without progression to AIDS for more than 8 years without therapy.

Journal of medical virology - 1 Dec 2012

De Maio Federico A, Rocco Carlos A, Aulicino Paula C, Bologna Rosa, Mangano Andrea, Sen Luisa

Abstract excerpt

The HIV-1 vif gene encodes for an accessory protein that is central for virus replication due mainly to its capacity to counteract the antiviral action of host APOBEC3 restriction factors. In order to evaluate whether HIV-1 vif alterations account for a delayed progression to AIDS in children infected perinatally, the vif genes from a group of 11 patients who exhibited an extremely slow disease progression (slow...

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Share to Acquired Immunodeficiency Syndrome
Share to APOBEC-3G Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Genes, Viral

Share to Genotyping Techniques

Share to Infectious Disease Transmission, Vertical

Share to vif Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 23080486
DOI: 10.1002/jmv.23261

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