Article
Genetic and functional analysis of HIV type 1 nef gene derived from long-term nonprogressor children: association of attenuated variants with slow progression to pediatric AIDS.
AIDS research and human retroviruses - 1 Dec 2012
Corró Guillermo, Rocco Carlos A, De Candia Cristian, Catano Gabriel, Turk Gabriela, Mangano Andrea, Aulicino Paula C, Bologna Rosa, Sen Luisa
Abstract excerpt
Among persons infected by HIV-1, the rate of progression to AIDS is multifactorial being affected by host and viral factors, including the HIV-encoded negative factor (Nef). Our aim was to define whether variations in the nef gene as well as its functions may be associated with slower HIV disease course in infected children. The proviral HIV-1 nef gene was cloned, sequenced, and compared in children with...
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